植入式生理信號無線遙測系統(tǒng)用于長時(shí)間測量清醒無束縛的大鼠、小鼠、兔子、比格犬、猴子、魚等多種動(dòng)物的心率、體溫和活動(dòng)量等生理參數(shù)。使用此系統(tǒng)可以保證動(dòng)物在籠內(nèi)自由活動(dòng)，不需要麻醉或束縛，這樣測量到的生理信號更能反映自然狀態(tài)下的動(dòng)物生理狀況?？捎糜谏锕?jié)律研究和相關(guān)的生命體征監(jiān)測。

植入式生理信號無線遙測系統(tǒng)可無線遙測和記錄實(shí)驗(yàn)動(dòng)物的：心率、體溫、活動(dòng)量.  

植入式生理信號無線遙測系統(tǒng)由植入體(E-Mitter)、接收數(shù)據(jù)轉(zhuǎn)換器(Receiver)、電纜和記錄分析計(jì)算機(jī)(VitalView)構(gòu)成。1厘米大小的植入體E-Mitter集成了傳感器、放大器和無線信號發(fā)射器，根據(jù)測量信號不同有多種規(guī)格。植入式E-Mitter轉(zhuǎn)發(fā)器不需電池，由接收數(shù)據(jù)轉(zhuǎn)換器(Receiver)輸出電力。實(shí)驗(yàn)人員將植入體埋入動(dòng)物皮下，生理信號被植入體采集到并轉(zhuǎn)換成相應(yīng)的電信號后用無線電發(fā)射出來，由飼養(yǎng)籠下方的接收器接收到并傳遞給數(shù)據(jù)轉(zhuǎn)換器，完成數(shù)據(jù)轉(zhuǎn)換后送入**處理器進(jìn)行數(shù)據(jù)處理。系統(tǒng)可同時(shí)連接32個(gè)接收器，完成大規(guī)模的試驗(yàn)。

植入體(E-Mitter)是植入在動(dòng)物體內(nèi)的微型設(shè)備,它集成了傳感器，放大器，數(shù)字轉(zhuǎn)換，無線發(fā)射的功能并解決了生物體的抗排異反應(yīng)。植入體有用于測量生物心率，體溫和活動(dòng)量等多種參數(shù)的規(guī)格。

植入式生理信號無線遙測系統(tǒng)的主要特點(diǎn)：

?     無線遙測

?     植入式E-Mitter轉(zhuǎn)發(fā)器沒有電池

?     長期監(jiān)測-植入裝置后允許連續(xù)、遙測實(shí)驗(yàn)動(dòng)物一生

?     準(zhǔn)確、可靠，報(bào)告清醒無束縛動(dòng)物的生理和行為數(shù)據(jù)

E-Mitter（植入體系統(tǒng)）主要技術(shù)參數(shù):

ER4000 信號接收器
ER4000信號接收器，用于給E-Mitters充電和接收E-Mitters傳回來的測量數(shù)據(jù)。適合標(biāo)準(zhǔn)的大小鼠飼養(yǎng)籠具。

信號接收器的主要參數(shù)

VitalView軟件

激發(fā)接收器和感應(yīng)器通過VitalView軟件連接到電腦?？梢杂涗?40個(gè)數(shù)據(jù)通道，典型應(yīng)用120個(gè)測試對象，對于E-mitter系統(tǒng)32個(gè)測試對象。

VitalView軟件可以設(shè)置實(shí)驗(yàn)參數(shù)和采集數(shù)據(jù)。軟件管理與硬件的連接，并且儲(chǔ)存顯示基本的圖形化的數(shù)據(jù)分析。軟件也提供統(tǒng)計(jì)形式的數(shù)據(jù)顯示，可以輸出數(shù)據(jù)。

如只需要測量大鼠、小鼠的核心體溫，可以選擇植入式體溫膠囊，對體溫?cái)?shù)據(jù)進(jìn)行遙測：

參考文獻(xiàn)：

1.Ganeshan, Kirthana et al. “Energetic Trade-Offs and Hypometabolic States Promote Disease Tolerance.” Cell vol. 177,2 (2019): 399-413.e12. doi:10.1016/j.cell.2019.01.050
2.Li, Yongguo et al. “Secretin-Activated Brown Fat Mediates Prandial Thermogenesis to Induce Satiation.” Cell vol. 175,6 (2018): 1561-1574.e12. doi:10.1016/j.cell.2018.10.016
3.Dodd, Garron T et al. “Leptin and insulin act on POMC neurons to promote the browning of white fat.” Cell vol. 160,1-2 (2015): 88-104. doi:10.1016/j.cell.2014.12.022
4.Pi?ol, Ramón A et al. “Brs3 neurons in the mouse dorsomedial hypothalamus regulate body temperature, energy expenditure, and heart rate, but not food intake.” Nature neuroscience vol. 21,11 (2018): 1530-1540. doi:10.1038/s41593-018-0249-3
5.Li, Jin et al. “Neurotensin is an anti-thermogenic peptide produced by lymphatic endothelial cells.” Cell metabolism vol. 33,7 (2021): 1449-1465.e6. doi:10.1016/j.cmet.2021.04.019
6.Pi?ol, Ramón A et al. “Preoptic BRS3 neurons increase body temperature and heart rate via multiple pathways.” Cell metabolism vol. 33,7 (2021): 1389-1403.e6. doi:10.1016/j.cmet.2021.05.001
7.Krisko, Tibor I et al. “Dissociation of Adaptive Thermogenesis from Glucose Homeostasis in Microbiome-Deficient Mice.” Cell metabolism vol. 31,3 (2020): 592-604.e9. doi:10.1016/j.cmet.2020.01.012
8.Sustarsic, Elahu G et al. “Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis.” Cell metabolism vol. 28,1 (2018): 159-174.e11. doi:10.1016/j.cmet.2018.05.003
9.Heine, Markus et al. “Lipolysis Triggers a Systemic Insulin Response Essential for Efficient Energy Replenishment of Activated Brown Adipose Tissue in Mice.” Cell metabolism vol. 28,4 (2018): 644-655.e4. doi:10.1016/j.cmet.2018.06.020
10.Dodd, Garron T et al. “A Hypothalamic Phosphatase Switch Coordinates Energy Expenditure with Feeding.” Cell metabolism vol. 26,2 (2017): 375-393.e7. doi:10.1016/j.cmet.2017.07.013
11.Keipert, Susanne et al. “Long-Term Cold Adaptation Does Not Require FGF21 or UCP1.” Cell metabolism vol. 26,2 (2017): 437-446.e5. doi:10.1016/j.cmet.2017.07.016
12.Wang, Tongfei A et al. “Thermoregulation via Temperature-Dependent PGD2 Production in Mouse Preoptic Area.” Neuron vol. 103,2 (2019): 309-322.e7. doi:10.1016/j.neuron.2019.04.035
13.Chavan, Rohit et al. “Liver-derived ketone bodies are necessary for food anticipation.” Nature communications vol. 7 10580. 3 Feb. 2016, doi:10.1038/ncomms10580
14.Jiang, Lin et al. “Leptin receptor-expressing neuron Sh2b1 supports sympathetic nervous system and protects against obesity and metabolic disease.” Nature communications vol. 11,1 1517. 23 Mar. 2020, doi:10.1038/s41467-020-15328-3
15.Walker, William H 2nd et al. “Acute exposure to low-level light at night is sufficient to induce neurological changes and depressive-like behavior.” Molecular psychiatry vol. 25,5 (2020): 1080-1093. doi:10.1038/s41380-019-0430-4
16.Zhang, Xue-Ying et al. “Huddling remodels gut microbiota to reduce energy requirements in a small mammal species during cold exposure.” Microbiome vol. 6,1 103. 8 Jun. 2018, doi:10.1186/s40168-018-0473-9
17.Ingiosi, Ashley M et al. “A Role for Astroglial Calcium in Mammalian Sleep and Sleep Regulation.” Current biology : CB vol. 30,22 (2020): 4373-4383.e7. doi:10.1016/j.cub.2020.08.052
18.Padilla, Stephanie L et al. “Kisspeptin Neurons in the Arcuate Nucleus of the Hypothalamus Orchestrate Circadian Rhythms and Metabolism.” Current biology : CB vol. 29,4 (2019): 592-604.e4. doi:10.1016/j.cub.2019.01.022