肺部液體霧化給藥器是上海玉研儀器專門為小鼠、大鼠、豚鼠等小動(dòng)物研發(fā)設(shè)計(jì)，可精確對(duì)氣管內(nèi)進(jìn)行霧化給藥的裝置。可將定量液體通過集成在不銹鋼毛細(xì)插管中的氣溶膠霧化微噴頭霧化，毛細(xì)插管可深入動(dòng)物至支氣管分叉處，實(shí)現(xiàn)氣管內(nèi)定量霧化成氣溶膠給藥。相較于傳統(tǒng)口服或注射給藥，藥物可直接作用于肺部，適用于肺部生理、病理、藥理學(xué)研究。

優(yōu)勢(shì)特點(diǎn)：

1.適用于小鼠、大鼠、豚鼠、兔子等小動(dòng)物，也可定制大動(dòng)物款
2.氣管內(nèi)直接給藥，無首關(guān)消除，藥物全身效應(yīng)小
3.微量精確給藥，藥物用量可達(dá)25μL（液體）
4.可用于溶液、小細(xì)胞懸浮液、均質(zhì)懸濁液、粘度較低的乳濁液等給藥
5.90%藥物霧化直徑≤30μm（液體），可達(dá)終末細(xì)支氣管甚至呼吸性細(xì)支氣管，可均勻分布于大小鼠肺部組織中
6.使用方便，安全穩(wěn)定，采用不銹鋼材質(zhì)，堅(jiān)固穩(wěn)定耐腐蝕
7.具有至少30篇高影響因子SCI文獻(xiàn)發(fā)表，可提供至少1篇IF大于35分的SCI文獻(xiàn)
8.設(shè)備具有CE認(rèn)證證書或EC符合性證書
9.可用于吸入毒理學(xué)、空氣生物學(xué)、生物危害測(cè)試、吸入免疫、吸入治*、藥物研究、環(huán)境評(píng)價(jià)、危害評(píng)估和醫(yī)學(xué)防護(hù)等多領(lǐng)域

應(yīng)用領(lǐng)域：

1. 研究肺部吸收機(jī)制：通過給予標(biāo)記的藥物,可以觀察藥物在肺泡和肺間質(zhì)中的吸收和轉(zhuǎn)運(yùn)過程，也可以準(zhǔn)確測(cè)定藥物在肺泡、肺間質(zhì)等不同部位的吸收速率和吸收程度，從而建立可靠的藥物吸收模型。

2. 分析肺部代謝過程 :使用肺部給藥技術(shù),可以檢測(cè)給藥后藥物在肺內(nèi)代謝產(chǎn)物的形成和變化，幫助分析肺部代謝酶的活性和代謝途徑，也可以分析藥物在肺內(nèi)的代謝動(dòng)力學(xué)，包括代謝速率、代謝產(chǎn)物的形成和清理。

3. 評(píng)估肺部清理機(jī)制：肺部給藥可作用于肺部，研究肺泡巨噬細(xì)胞、肺表面活性物質(zhì)、纖毛運(yùn)動(dòng)等對(duì)藥物清理的影響。

4. 探索肺部免疫反應(yīng)和屏障功能：通過肺部給予免疫刺激藥物，可以觀察肺部免疫細(xì)胞的激*和炎癥反應(yīng)。使用標(biāo)記的粒子或大分子作為探針，可以評(píng)估肺血管內(nèi)皮、上皮等屏障結(jié)構(gòu)對(duì)物質(zhì)通透性的調(diào)控作用。

5.建立肺部-全身循環(huán)的藥動(dòng)學(xué)模型：通過肺部給藥數(shù)據(jù)，可以建立詳細(xì)的肺部-血漿-全身循環(huán)的藥動(dòng)學(xué)模型，更準(zhǔn)確地預(yù)測(cè)藥物在體內(nèi)的吸收、分布、代謝和清理過程。

氣管內(nèi)給藥示意圖

肺纖維化大小鼠模型

傳統(tǒng)經(jīng)典的復(fù)制肺纖維化大小鼠模型方法是通過氣管內(nèi)滴入博萊霉素溶液，其主要方式有兩種：有創(chuàng)氣管切開滴注以及無創(chuàng)經(jīng)口氣管滴注。有創(chuàng)氣管切開滴注會(huì)對(duì)實(shí)驗(yàn)動(dòng)物造成外源性損傷，增加了實(shí)驗(yàn)動(dòng)物失血過多和感*的風(fēng)險(xiǎn)，無創(chuàng)經(jīng)口氣管滴注可引起明顯的肺組織損傷與肺纖維化改變，但溶液呈液滴狀進(jìn)入肺內(nèi)，其液滴相對(duì)較大，藥物較集中，容易造成動(dòng)物窒息死亡。

無創(chuàng)經(jīng)口氣管內(nèi)霧化給藥則是一種更新、更有效的促進(jìn)藥物肺內(nèi)均勻分布的方法，可以將博萊霉素溶液分散為體積更小的液滴，在氣流的推動(dòng)下，分散的液滴能進(jìn)入各肺葉，并可到達(dá)外周肺組織，因此造成累及各肺葉、出現(xiàn)程度相近的纖維化改變、范圍更彌散的肺組織損傷，更接近人類肺纖維化改變。氣管內(nèi)霧化博萊霉素溶液對(duì)小鼠的創(chuàng)傷小，很少出現(xiàn)窒息的情況，且不需穿刺氣管，減少了動(dòng)物的損傷與痛苦，降低了實(shí)驗(yàn)鼠的死亡率，并且藥物劑量可以準(zhǔn)確控制，實(shí)驗(yàn)結(jié)果重復(fù)性好，可作為復(fù)制肺纖維化大小鼠模型的良好方案。

由于大小鼠肺部疾病模型造模指向性強(qiáng)，需要直接將造模藥物均勻輸送到肺組織中。因此包括**模型，肺纖維化模型，急性肺組織損傷模型，病毒感*模型等肺部疾病模型均可使用經(jīng)口氣管內(nèi)霧化給藥造模。

相關(guān)產(chǎn)品推薦：

合適的工具能幫助您更好地完成工作，氣管插管臺(tái)和小動(dòng)物喉鏡是幫助您完成肺部給藥手術(shù)的得力助手，推薦與肺部干粉霧化給藥器配合使用。

氣管插管平臺(tái)

氣管插管平臺(tái)支持小鼠、大鼠等小動(dòng)物在一個(gè)穩(wěn)定舒適的方位開展氣管插管、藥物灌注及其它類似實(shí)驗(yàn)操作?？梢愿鶕?jù)需要進(jìn)行不同孔位的固定，進(jìn)行多種操作角度的調(diào)節(jié)，滿足不同實(shí)驗(yàn)類型以及實(shí)驗(yàn)動(dòng)物種類的需求。雙面操作模式，使得肺部給藥操作更為流暢順利，可與我公司小動(dòng)物呼吸機(jī)、麻醉機(jī)、肺部定量給藥器、喉鏡等配合使用，也可根據(jù)要求進(jìn)行定制。

CG-02型

CG-04型   

CG-06型

小動(dòng)物喉鏡

SR310型小動(dòng)物喉鏡，用于觀察實(shí)驗(yàn)動(dòng)物的喉部等結(jié)構(gòu)，以進(jìn)行肺部給藥、經(jīng)口氣管插管等操作，適用于小鼠、大鼠、豚鼠，也可根據(jù)您的要求進(jìn)行定制。采用光纖LED照明系統(tǒng)，提供清晰明亮的光線，給觀察喉部、會(huì)厭等結(jié)構(gòu)的操作人員提供了更好的視野。前端為不銹鋼的葉型尖部，可隨時(shí)拆卸或更換。操作柄的形狀符合人體工程學(xué)，使操作更舒適方便。

產(chǎn)品特點(diǎn)：

1.外殼采用金屬材質(zhì)，堅(jiān)固耐用，易清洗                    

2.操作柄的形狀符合人體工程學(xué)的原理，手握舒適 

3.專為大小鼠口腔結(jié)構(gòu)設(shè)計(jì)的特制葉片，解決了因口腔太小難以插管的難題 

4.具有大鼠葉片和小鼠葉片供選擇 

5.葉片采用不銹鋼材質(zhì)，很大限度地減少腐蝕，確保耐用 

6.電池采用兩節(jié)5號(hào)電池，方便更換

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